Avoid the high cost of chasing false leads. Focus your investigation with Snapshot.

Snapshot is a revolutionary new forensic DNA analysis service that accurately predicts the physical appearance and ancestry of an unknown person from DNA. It can also determine kinship between DNA samples out to six degrees of relatedness. Snapshot is ideal for generating investigative leads, narrowing suspect lists, and identifying unknown remains.

Starting with extracted DNA or biological evidence from your case, we will produce a detailed Snapshot report and composite profile that includes eye color, skin color, hair color, face morphology, and detailed biogeographic ancestry. Armed with this scientifically objective description, you can conduct your investigation more efficiently and close cases more quickly.

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“A fantastic breakthrough!”
John Walsh, Guest Host of Cold Justice and America's Most Wanted
“This [Snapshot] is such a huge investigative tool now.”
Cami Green, Sales Manager, Sorenson Forensics®
“Snapshot gave us 100% more investigative information about
the perpetrator than we had before the analysis.”
Detective Brenton Groeneveld, Warwick RI Police Department
“Parabon gave us an option we otherwise didn't have: a Snapshot
composite we could share with the community. They were great partners!”
Major Terri S. Molina, Coral Gables FL Police Department
“We are excited about this [Snapshot] result. It totally redirects our
whole investigation and will move this case in a new direction.”
Sheriff Tony Mancuso, Calcasieu Parish LA Sheriff's Office
“It was amazing! Even the facial
bone structure was spot on.”
Yolanda McClary, Investigator for TV's Cold Justice
What DNA
Phenotyping Is

The Snapshot DNA Phenotyping Service

DNA Phenotyping is the prediction of physical appearance from DNA. It can be used to generate leads in cases where there are no suspects or database hits, or to help identify unknown remains.

The Parabon Snapshot DNA Phenotyping Service

DNA carries the genetic instruction set for an individual's physical characteristics, producing the wide range of appearances among people. By determining how genetic information translates into physical appearance, it is possible to "reverse-engineer" DNA into a physical profile. Snapshot reads tens of thousands of genetic variants ("genotypes") from a DNA sample and uses this information to predict what an unknown person looks like.

Over the past four years, using deep data mining and advanced machine learning algorithms in a specialized bioinformatics pipeline, Parabon — with funding support from the US Department of Defense (DoD) — developed the Snapshot Forensic DNA Phenotyping System, which accurately predicts genetic ancestry, eye color, hair color, skin color, freckling, and face shape in individuals from any ethnic background, even individuals with mixed ancestry.

Because some traits are partially determined by environmental factors and not DNA alone, Snapshot trait predictions are presented with a corresponding measure of confidence, which reflects the degree to which such factors influence each particular trait. Traits, such as eye color, that are highly heritable (i.e., are not greatly affected by environmental factors) are predicted with higher accuracy and confidence than those that have lower heritability; these differences are shown in the confidence metrics that accompany each Snapshot trait prediction.

Phenotyping Works

How DNA Phenotyping Works

Snapshot takes advantage of modern SNP technology, translating select biomarkers from a DNA sample into predictions about various physical traits of its source. Using these predictions, Snapshot generates a descriptive profile that contains sex, ancestry, pigmentation (skin color, hair color, eye color, freckling), and even face morphology, as well as excluded phenotypes.

SNP Technology

Recent advances in DNA sequencing technology have made it practical and affordable to read genetic content from DNA, which in turn has allowed the creation of datasets that include both genotypic (genetic content) and phenotypic (trait) data for each of thousands of subjects. With the diligent and repeated application of data mining and machine learning processes to such data, Parabon NanoLabs produces statistical models that translate the presence of specific genetic biomarkers into forensically relevant trait predictions.

Mining and Modeling Genotype Data

Using genomic data from large populations of subjects with known phenotypes, Parabon's bioinformaticists have built statistical models for forensic traits, which can be used to predict the physical appearance of unknown individuals.

Data Mining

Beginning with large datasets comprised of a phenotype (trait) of interest and genotype data for thousands of subjects, our bioinformatics team performs large-scale statistical analysis on millions of individual SNPs and billions of combinations thereof to identify sets of these genetic markers that associate with the given trait. This mining process can take weeks running on hundreds, sometimes thousands, of computers. In the end, those SNPs with the greatest likelihood of contributing to the variation observed in the target trait are culled for potential use in predictive models.

Data Modeling

The modeling phase further refines this set of SNPs to a final set that most accurately predict the target trait under a framework of machine learning algorithms. Models are validated against data held out for such testing and calibrated with all available data before being installed into the Snapshot architecture.

Tested on thousands of out-of-sample genotypes, Snapshot's trait predictions have been shown to be highly accurate. For example, Snapshot predicts pigmentation traits with an average accuracy of greater than 80%, and its ability to discriminate between pigmentation extremes is considerably higher — often 99% or more.

Even in cases where it is difficult to distinguish between two similar phenotypes — e.g., hazel eyes vs. green eyes — Snapshot can, with high confidence, exclude certain traits (for instance, Snapshot can, with confidence approaching 100%, predict that a particular subject does not have brown or black eyes.

Use Cases

DNA Phenotyping Use Cases

Snapshot was built for the defense, security, justice, and intelligence communities. The technology has been validated with as little as 50 picograms (0.05 nanograms) of DNA, from which high-quality genotypes of nearly 1 million SNPs have been produced with very high call rates.

The development of Snapshot took four years and was funded by the United States Defense Threat Reduction Agency (DTRA). As part of the development and validation process, Snapshot was tested on thousands of out-of-sample genotypes and was shown to be extremely accurate. In addition, Snapshot has been used by State and local police departments throughout the US, and private citizens seeking ancestry information.

Snapshot can be applied to any case where DNA has been found that does not match a known suspect or CODIS. Snapshot provides a means to determine the physical appearance and other characteristics of the individuals that are the source of such samples.

Instead of being stymied by DNA evidence that fails to produce a database match, investigators can now use Snapshot to generate viable leads in cases that might otherwise go cold.

Schedule a Free Online Demo
of Actual Police Dept. Evaluation Results

What Ancestry
Determination Is

Predicting Genetic Ancestry With Snapshot

Scientific analysis of human genomes from different parts of the world has shown that, on a global scale, modern humans divide genetically into seven continental populations: African, Middle Eastern, European, Central/South Asian, East Asian, Oceanian, and Native American1. These genetic divisions stem simply from the fact that these groups were isolated from one another for many generations, and thus each group has a unique genetic signature that can be used for identification. In order to determine a new subject’s genetic ancestry, Parabon Snapshot analyzes tens of thousands of SNPs from a DNA sample to determine a person's percent membership in each of these global populations. Other forensic ancestry approaches assume that every individual comes from only a single population, so they can easily be confounded by admixed individuals, but Snapshot allows for contributions from multiple populations, so it can detect even low levels of admixture (<5%).

Global Ancestry Map

Global ancestry map showing mostly East Asian and Native/South American ancestry, with some European ancestry as well.

After global ancestry is determined, Snapshot's ancestry algorithm investigates which subpopulations (e.g., Northwest vs. Northeast Europe) an individual comes from. This analysis is robust to admixture, such that each piece of continental ancestry can be precisely localized within that continent. For example, the admixed East Asian and Latino example from the global map above was determined to have specifically Japanses, Central American, and Southwest European ancestry, as shown in the map below.

Regional Ancestry Map

Regional ancestry map showing mostly Japanese, Southwest European, and Central American ancestry.

Using all of this information, Snapshot builds a precise profile of an individual's ethnic ancestry using only his or her DNA.

How Ancestry
Determination Works

How Genetic Ancestry Determination Works

Parabon has built a powerful system for determining ethnic ancestry from DNA. Most other forensic ancestry systems use only a small number of SNPs and thus are limited to very coarse populations and cannot detect admixture between populations. Snapshot uses tens of thousands of SNPs across the genome to obtain very precise estimates of ancestry, even for admixed individuals. Parabon’s scientists have collected data from many published scientific articles, totalling more than 9,000 individuals with clearly defined ancestry from more than 150 populations around the world, as shown in the map below.

Ancestry Populations

Each point represents a population from which we have obtained ancestry background data. Efforts are ongoing to increase the representation of Native American populations.

Academic research using hundreds of thousands of SNPs from across the genome has shown that human groups generally divide into seven continental populations, which have been established over the past 50,000 years during the migration out of Africa. The 150 populations collected as the ancestry background can thus be divided into these seven continental groups according to their origin.

Snapshot builds on this research by mapping a new person's genome onto these established populations. Our algorithm calculates how similar the new individual's DNA is to each of the background populations, determining which population(s) the person comes from. This allows for contributions from multiple groups, so even small amounts of admixture (<5%) can be detected.

Snapshot takes a similar approach to identifying within-continental (regional) ancestry, although the local populations were identified through empirical analysis performed by our bioinformatics team. Each piece of continental ancestry is partitioned according to its regional ancestry (e.g., if an individual is 50% European and 50% East Asian, the precise origin of each of those pieces will be determined). The person's genome is also plotted against all of the known individuals in each region to show visually where he or she falls.

Below is an example plot for an individual who was determined to be 50% East Asian and 50% Latino. Latino ancestry is a mixture of European and Native American ancestry, so these groups are shown as well.

Regional Ancestry Clustering

Ancestry clustering diagram; this individual is half Japanese and half Latino.

Use Cases

Ancestry Determination Use Cases

Ethnic ancestry is one of the most informative traits that can be predicted from DNA. In an ancestry analysis, Snapshot will determine an individual's precise genetic origins, as well as whether there is any evidence of admixture (contribution from multiple populations). This information can be used to help identify remains or to significantly focus an investigation by excluding a wide range of possible suspects or even pointing to a very small group.

Schedule a Free Online Demo
of Actual Police Dept. Evaluation Results

What Kinship
Inference Is

Snapshot Extended Kinship Analysis

Parabon Snapshot can provide inferences about the familial relationship between the sources of two or more DNA samples.

Kinship ChartKinship Legend

Built with machine learning, the Snapshot kinship model can distinguish up to 6th-degree relatives from unrelated pairs.

Using the power of genome-wide SNP data, it is possible to precisely calculate the degree of relatedness between two people, even if the relationship is very distant. Whereas traditional STR-based kinship analysis is limited to distinguishing parent/offspring relationships, Snapshot's kinship model uses hundreds of thousands of SNPs to identify up to 6th-degree relationships while preventing false positives (unrelated pairs mistakenly inferred to be related).

How Kinship
Inference Works

How Distant Kinship Inference Works

Parabon's scientists were not satisfied with the kinship solutions developed by academics and chose to develop a new algorithm that takes advantage of the massive amount of data made available by genome-wide SNP typing to compare two genomes and determine the precise degree of relatedness between the two individuals.

Traditional kinship analysis uses fewer than 20 short tandem repeat (STR) loci, which lack the resolution to establish relatedness beyond parent-offspring or full siblings, and is easily confounded by mutation or mistaken testing of a close relative of the true parent1.

More advanced analyses use pieces of DNA that are directly transmitted through the maternal (mitochondrial DNA) or paternal (Y-chromosome) lines; however, these approaches are limited to a small subset of relationships and are very low resolution. For example, ~7% of unrelated Europeans share the same mitochondrial haplotype. MtDNA and Y-STRs can only suggest that two individuals may be related but cannot say what the degree of relatedness is.

Parabon's kinship algorithm analyzes the similarity between two genomes and uses a machine learning model to predict the degree of relatedness of the two individuals. In more than 1,000 out-of-sample predictions, this method has proven to be highly accurate while maintaining a very low false-positive rate (i.e., unrelated pairs are almost never mistakenly inferred to be related). Accuracy is 100% for parent-offspring, full siblings, and 2nd-degree relatives — i.e., grandparents, aunts and uncles, and half-siblings — and Snapshot can distinguish 6th-degree relatives (e.g., second cousins once removed) from unrelated pairs with greater than 97% accuracy.

As shown in the figure below, even when Snapshot incorrectly infers the degree of relatedness between two individuals, it is almost always correct within one degree:

Kinship Accuracy

Snapshot Kinship Accuracy, measured as the frequency of correct predictions of the exact degree of relatedness (absolute accuracy) and the frequency of predictions within one degree of relatedness (n = 1,282 relationships). All relationships are defined relative to the black square.

Use Cases

Who Uses Distant Kinship Analysis

The Snapshot kinship capability can be used to establish familial relationships between a DNA sample and previously collected DNA samples or among a set of new samples.

Knowledge of these relationships can be used to validate claims of distant kinship, establish relationship networks within groups of interest, or identify remains when close relatives are not available, such as cold cases, mass disasters, or casualties of past conflicts.

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of Actual Police Dept. Evaluation Results

Forensic Art
What Forensic Art
Enhancement Is

Forensic Art Enhancement

While DNA can reveal much about the appearance of a subject, information about features like age, body mass index (BMI) or the presence of facial hair are not available within an individual's genetic code. Snapshot forensic art services provide a means of incorporating such information into a Snapshot composite when it is available from non-DNA sources.

Five faces, aged 25 through 75, some with beards and some without

Examples of age progression and accessorization with Snapshot Forensic Art Services. By default, Snapshot produces composites from DNA at 25 years of age (A). Composite (A) shown after age progression to age 50 years (B); with the addition of a light beard (C); after further age progression to age 75 years with reading glasses (D); and with a full beard (E)

Using forensic artists certified by the International Association for Identification (IAI), we provide age progression, BMI alteration and accessorization, which can include the addition of facial hair, eyeglasses, piercings, etc. We can also create composite sketches from eyewitness accounts and combine them with traditional Snapshot composites; in this way, corroborating the witness account or adding objective phenotype information to help ensure the most accurate composite.

Three faces: one aged 25, one aged 52 with a beard, and
   an actual photo of the subject

Composite (A) shown after age progression to 50 years old, including a beard (B) as compared to the actual subject (C)

In cases involving unidentified remains where a skull or partial skull is available, our forensic artists are also trained to perform digital facial reconstruction, using bone structure to enhance or give nuance to a Snapshot composite. Collectively, these forensic art services perfectly complement what Snapshot can provide from DNA alone and together they represent a revolution in how DNA can be used in an investigation.

How Forensic Art
Enhancement Works

How Forensic Art Enhancement Works

Forensic artists are artists with special training to address forensic challenges. They have an expert understanding of the human face and how the effects of aging and body mass index (BMI) change appearance. Those trained in facial reconstruction learn how to infer the most likely distribution of muscle and soft tissue from a skull. Forensic artists who create composite sketches from eyewitness accounts are trained to conduct cognitive interviews, so as to get the most accurate portrayal from a witness' memory.

Like many domains, forensic artists are beginning to rely heavily on modern software applications to facilitate their work. Sketches formerly performed with pencil and pad can now be drawn digitally. As well, facial reconstructions once performed with clay sculpture can also be digitally sculpted. In the right hands, graphics software programs can ease the task of adding or subtracting hair, scars, and other accessories. In all cases, great skill and specialized training is still required, but the work can be more efficient and realistic thanks to these tools.

Forensic Art
Use Cases

Forensic Art Enhancement Use Cases

There are a number of use cases for which forensic art can be used.

Age Progression or Regression

Because age is not genetically encoded, Snapshot predicts subjects at 25 years of age by default. When investigators have reason to believe a person of interest is younger or older, our artists can adjust a composite accordingly, based on standard aging principles.

Three faces: the predicted composite at age 25, one aged to 52 years old, and one aged to 75 years old

Examples of age progression with Snapshot Forensic Art Services: the predicted composite at 25 years old (A); shown after age progression to age 50 years (B); and after further age progression to 75 years of age

Composites Based on Eyewitness Account

Our forensic artists are trained to conduct cognitive interviews and produce composites solely from an eyewitness account. The interview and composite production is conducted online with screen sharing technology, so eyewitnesses do not have to travel. When DNA is available for the same person of interest as seen by the eyewitness, Snapshot can provide a corresponding composite from "the genetic witness" perspective. Our artists can combine a composite from an eyewitness account with one produced by Snapshot to produce a single, highly accurate rendering that contains the best that both sources of information can offer.


In some instances, descriptive information about a subject's accessories or distinguishing features is available that can be used to enhance a Snapshot composite. For example, a surveillance camera image may be too grainy for identification, but nevertheless suggestive that a suspect has facial hair. Similarly, an eyewitness may recall a tattoo or scar, even though they were too traumatized to remember much else. In such cases, our forensic artists can accessorize a Snapshot composite to include all available descriptive information about a subject.

Three faces: one normal at 25, one with a beard at 52, and one with a beard at 75

Examples of accessorization with Snapshot Forensic Art Services: the predicted composite at 25 years old (A); shown after age progression to age 50 years, with the addition of a light beard (B); and after further age progression to age 75 years with reading glasses and a full beard (C)

Body Mass Index (BMI) Alteration

Besides the effects of aging, changes in BMI have among the largest effects on appearance. By default, Snapshot produces composites assuming the subject has a BMI of 22, which is considered average. When information is available that suggests a subject has a lower or higher than average BMI, forensic artists can appropriately alter the BMI of a Snapshot composite.

Three faces: one normal, one gaunt, and one obese

Extreme examples of body mass index (BMI) alteration: the original prediction (A); shown with significantly less body mass (B); and again with a significantly larger amount of body mass (C)

Unidentified Remains

When unidentified human remains include a skull, our forensic artists can perform facial reconstruction, literally building up the corresponding face using knowledge of facial musculature and soft tissues. Although facial features cannot be perfectly inferred from a skull, bone structure can be immensely informative about the shape of an individual's face. Snapshot predicts exterior face morphology, but when a skull is available, a forensic artist can use it to confirm or enhance a Snapshot composite based on facial reconstruction.

Schedule a Free Online Demo
of Actual Police Dept. Evaluation Results

For ordering information, please email snapshot@parabon-nanolabs.com or call (703) 689-9689 x251